Probably not. It's one of if not the most sophisticated air-defense on the planet. Without overwhelming it, attacks have little chance of any significant successes.

Just look at Ukraine, most attacks never reach their target and they are probably not equipped as well as Israel is (and also spread out much further). Even Russia's "hypersonic" missiles are shot down by plain ol' patriot systems on the regular.

So unless Iran pulls out some really fancy tricks, they will probably just hit low-value targets or maybe manage to overwhelm the defense in some limited areas (at the cost of a lot of drones). If this was to drag on however, it'll start to hurt eventually...