Not sure about pill treatments but I had tried a bunch of ineffective things before a friend recommended me one of these Seresto collars.
They're just magic man, I don't know. My dog and cat used to consistently get fleas, but a couple of weeks after I got them one of those, every freaking bug just vanished. Nothing ever since, as far as I can tell (I still check them often).
If anyone knows how these works, I'd love to be enlightened!
I've been finding Zulip quite helpful. It's threading model is great and they overall focus quite a bit in the project coordination use-case. You can either self-host it or pay for their managed hosting (which is free for open-source projects), and you can add a plugin to make static HTML pages of streams (aka channels) in order to make stuff indexable and searchable (and iirc this is getting polished and built into Zulip's core).
If you care about accessibility, email is still the best choice — it's mostly text-focused, doesn't need an account (besides what is universally seen as the most basic Internet identity), truly decentralized and has mature tooling. I just haven't found a really good mailing list archive web UI. HyperKitty is good, but isn't quite there for me. lists.sr.ht is neat, but lacks a lot of features. Above all, indexability and searchability (from inside the UI itself) is key.