Selfhosted
A place to share alternatives to popular online services that can be self-hosted without giving up privacy or locking you into a service you don't control.
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Thee main issues are latency and bandwidth, especially on a server with limited RAM. If you're careful to manage just the data over NAS, it's probably fine, especially if the application's primary job is server data over the same network to clients. That will reduce your effective bandwidth, as data has to go NAS->server->client over the same wires/wifi. If the application does a lot of processing, like a database, you'll start to compromise that function more noticeably.
On applications with low user count, on a home network, it's probably fine, but if you're a hosting company trying to maximize the the data served per CPU cycle, then having the CPU wait on the network is lost money. Those orgs will often have a second, super-fast network to connect processing nodes to storage nodes, and that architecture is not too hard to implement at home. Get a second network card for your server, and plug the NAS into it to avoid dual-transmission over the same wires. [ed: forgot you said you have that second network]
The real issue is having application code itself on NAS. Anytime the server has to page apps in or out of memory, you impose millisecond-scale network latency on top of microsecond-scale SSD latency, and you put 1 Gb/s network cap on top of 3-6 Gb/s SSD bandwidth. If you're running a lot of containers in small RAM, there can be a lot of memory paging, and introducing millisecond delays every time the CPU switches context will be really noticeable.