StringTheory

Are you talking about internal hubs? There are many bikes with internal hubs available in the US, far more than bikes with Pinions. Even department/sports stores like REI sell bikes with internal hubs. I have 4 bikes with internal hubs, one is a CVT which is a hoot to shift but heavy as heck.

Rental prices https://culdesac.com/tempe/apply/unit-selection/

So abused kids grow up to have smaller hippocampi, but not every person with a small hippocampus also has major depression?

I’m gonna be really shallow and judgmental and just say her picture is creepy, too. What a bizarre pose and expression.

Does the company that bought Osprey still honor the warranty?

Keen Newports have the finger loops on tongue and heel. I think Blundstone boots do, too? I’m sure someone with Blundstones can confirm or refute that.

Those loops are so handy, I agree.

Bicycle. No gas expenses, no tabs, no loan, free parking. I understand how it works and can mostly fix it myself for very little money. I can take quiet side streets and arrive in a much better mood, plus my fat lazy ass gets some exercise.

This is the cool part:

But histotripsy foils cancer’s cloaking efforts by destroying its cell walls, leaving the tumor antigens in plain sight for the body’s immune system.

This effect was detailed in a pair of papers published by the U-M research team between March 2022 and January 2023. They demonstrate that the sound waves used to break down cancerous tumors in rats also helped trigger the rats’ immune response. After histotripsy destroyed 50% to 75% of liver tumor volume, the rats’ immune systems cleared away the rest, with no evidence of recurrence or metastases in more than 80% of animals.

That immune response occurred throughout the body, not just in areas targeted by the histotripsy treatment, resulting in the reduction of tumors far from the treated area.

The immune response is key. Without it, histotripsy is just yet another way to destroy a tumor without curing the cancer.

There have been similar studies looking at “feeding” mannose to solid tumors. The starve-the-tumor-with-fake-nutrients option has a lot of potential.

Not sure I want my neighbor pawing through my mail, or “accidentally” losing my ballot, or borrowing” my packages.

Privacy and security in the mail is crucial.

People are people. Human nature isn’t going to change just because the culture shifts to solarpunk.

Coffee makes me incredibly hungry (any caffeine does). This would backfire on me soooooo bad.

I have to wonder if an extra cup of any liquid per day would help avoid weight gain. You hear so much about people misinterpreting thirst as hunger - they eat instead of drinking.

Something like the Forest Schools and outdoor schools/daycares now. Students outdoors and engaging with the real world and each other nearly all the time. Nothing stripped to dry and abstract isolated bits (and boring) but always learning concepts in context and seeing how they interact.