Eternal Darkness: Sanity's Requiem. You play as many characters, but the primary main character is Alexis Roivas.
Gaming
From video gaming to card games and stuff in between, if it's gaming you can probably discuss it here!
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See also Gaming's sister community Tabletop Gaming.
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How about Final Fantasy XIII? The first game has a full sized party, but Lightning is clearly the main character and the focus. Second game costars Lightning's younger sister and a new male character. Third game is just Lighting.
Kena: Bridge of Spirits is good. I still gotta finish it, but I've enjoyed it so far.
Skullgirls!
The only game that comes to my mind now that hasn't been mentioned yet, would be Tchia. Very sweet game.
Castlevania: order of ecclesia
Cross code
Oceans heart
Alice games
Stardew valley
Metroid: Fusion is pretty fun!
Gravity Rush
Resident Evil 5.
Sheva is a badass.
The tomb raider Trilogie
If you're into farming and dungeon delving, Rune Factory 4 has a female protagonist option.
Rune factory 4 actually came to PC as of 2021 so you don't have to own a 3ds to play it anymore. I'm currently playing RF5, and I'm enjoying it.
The Longest Journey, Dreamfall, Dreamfall Chapters
This is what I was coming here to recommend. April is a great character, and the series is really good. The first is very much old-school point & click, with the sometimes highly obscure puzzles that entails, but the story is excellent.
there's a demo for a game on steam called Laika: Aged Through Blood which has a badass motorcycle mom
If we are doing demos too, there is also the Boomer Shooter 'Selaco' on Steam. It's just the first level in the demo and there isn't much story so far. But it looks very promising I think and we play as Dawn, a female Captain and murder a bunch of terorist that want to blow us up. They want to announce their release date next quarter.
Another Boomer Shooter with a female lead is 'Ion Fury'. This one has already released some years ago. We play Shelly 'Bombshell' Harrison and are part of the Global Defense Force. After a long shift we want to settle down with a nice drink as an explosion causes us to spill it and cyborg cultists led by an evil Dr. want to take over, so we go murder them.
Staying with shooters there is also 'Nightmare Reaper' where we play a female mental patient and the levels are her dreams which are created proceduraly and I guess we cleanse them of her nightmares.
Back to demos but a completely different genre: 'Sea of Stars'. An old school rpg, kinda reminds me of Chrono Trigger gameplay wise. It's made by the folks who made 'The Messenger', different genre again and no female protagonist in this one. But in there was a story tidbit about two kids with the power of the moon and the sun who saved the world a long time ago. We play those kids and the kid with the power of the moon is a girl. Again, just a demo on Steam so far but it looks very fun and releases on the 29th of August.
What constitutes a good game is obviously very subjective and as probably became very clear I like me some Boomer Shooter where the story doesn't necessarily needs to be the focus, but that won't be to everyones taste.
Passing By (I think Curly is technically gender-neutral but I always saw her as a girl).
I think the download files got taken down though unfortunately
Edit: Apparantly they've been canonically made non-binary
I enjoyed the chill, stylized vibes in Sable. Coming of age, botw-inspired exploration, beautiful world. No (?)Combat—I don’t remember fully, but very little at least. Just explore, experiment, and engage the world around you. A passable world-build/story too!
Good is an incredibly subjective term. May be you can try Control. Or, if you're into rythm games and metal, I'd recommend Metal: Hellsinger.