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I don't do autopsies at my current job, but I have been trained to do so in school. Overall, I have not done very many autopsies at all in comparison to many peers in my field. I would not feel comfortable doing one on my own at this point due to lack of experience. I never really saw that many that were particularly sad tbh, but there were several that stood out to me.
Someone who died of suicide. The autopsy itself wasn't overly depressing tbh, just fairly routine, but the person had left a suicide note. It was read aloud to us. To hear about all the pain that person was going through and to hear them talk about things about themselves that I knew were untrue really made me almost start crying tbh. They had family members who loved them, but they had felt that they were a burden to their family and killed themselves.
A teen who died of lymphoma. I can't remember if they had just turned 18 or they were about to, but it was sad to hear of such an innocent life cut so short in such an unfair way. I have not done autopsies on anyone younger, but I know people who have.
A woman who died suddenly around Christmastime of a pulmonary embolism. There wasn't much to the case that got to me, but I remember noting that her nails were painted in a festive red and green. It indicated to me that she had been looking to enjoy the holidays, but that she never ended up getting to experience them with her loved ones. When many people perform an autopsy, there is a distinct emotional separation many of us have from the decedent and a "real" human being, if that makes sense. But little things like that remind you that these were real people with real lives and real emotions and real hopes and dreams.
Honestly, most autopsies I have seen/done were on older/elderly people who either died of natural causes or alcoholism. There was also occasional drug overdose deaths who tended to trend a lot younger. It never made me feel all that bad if someone had died older tbh because they had a chance to live their lives. It's the younger ones that were always more notable.