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I don't know the science and medicine, but Seroquel helps me sleep at night (I am bi-polar). When I was in my 20s, a much larger dose did nothing for me. Many years later, we tried it again because physiology changes. Now it works. Too much and it's hard to wake up in the morning.
I still liked taking a strong dose of Halcyon better. I could pop up in the morning feeling fantastic. But my current doc won't let me have it except when I need to wake up and drive in the morning because it's "habit-forming." The Seroquel leaves me a little hazy for a while, so when we were two days in office after the pan rescinded, that'd be a Halcyon sleep. Luckily, my current gig is a ten minute walk from home.
Yeah Quetiapine knocks me out. I'm unsure how people who take it for psychoses can take that at ten times the dose and function.
I mean, as stated previously, I took a much larger dose and it had no effect 20y ago. Something was different about how my body processed it. I would be leveled by a large dose today. Brains are weird.