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Revealed: WHO aspartame safety panel linked to alleged Coca-Cola front group
(www.theguardian.com)
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Just as easily as a molecule with two carbons, one nitrogen, one oxygen, and a hydrogen. Just because chemicals are simple doesn't mean they are safe.
That's not really an answer. Any impact that aspartame would have, the same impact would occur from phenylalanine and aspartic acid consumption. And considering we both have no evidence for such impacts and both amino acids are critical for this whole being alive thing, that means there is no biochemical basis for claims of harm in the first place.
My point is that just because a compound is simple or easily understood doesn't mean it is safe. What if excess phenylalanine is toxic? It's not completely outside of the realm of possibility.
For the record, I agree with you that it is unlikely that aspartame is toxic and the only studies that show this use non-human analogues. It is, however, important to play devil's advocate in scientific settings.
I read some study that aspartame changed the gut flora. Sugar probably does the same thing though. But sometimes there's interactions that science forget to study