As someone who recently switched to Linux and doesn't like to tinker much and doesn't have very deep knowledge of Linux, I'll share my experience. Whether you ultimately try or not is up to you.

Your requirements for accessibility suggests you should look into a distro with KDE Plasma as many said already. It is an extremely flexible and customizable DE.

I personally started with Mint and ended up somewhat wedging KDE in it because I didn't like how cinnamon was handling multiple monitors. It worked but was a little rough around the edges in that setup, as it should be expected with a distro running a DE it wasn't meant to. If you don't mess with the DE however I've found Mint to be super easy and approachable. But ultimately it might not be what you need.

After doing a lot of research and comparisons I then switched to OpenSUSE Tumbleweed with native KDE plasma. A few things took a little extra tinkering and learning to get them to work but after that it became the setup I am happy to stick with for a long while.

I have no experience with them but KUbuntu and Fedora Plasma Spin might be also good alternatives to look for.

Running games is very easy through stream and still relatively easy with Bottles, which is rather easy and straightforward to lean to use. As long as you have the right video drivers installed. I have an NVidia card which made it a little more complicated but I made it work still. My understanding is that this shouldn't be any issues with AMD cards right out of the box.

Ultimately it will require you to learn a little here and there whenever you come across something you don't know. But as someone who only has an extremely shallow understanding of how the OS works and basic common console commands I have found no problem so complicated that I couldn't handle with a quick web search.