There are two potential show-stoppers.
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Field-specific apps that only run on windows. If you really need Adobe Creative Cloud or SolidWorks or something like that you might be out of luck. This is mostly true for apps that require GPU acceleration, which is difficult to rig up in a VM. You wouldn't want to do that if it was a big part of your workload.
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Mandatory spyware and rootkit DRM to prevent cheating with remote tests. Hopefully if they do such a thing they provide loaner hardware too. I've seen a lot of bullshit in my time but my experience is outdated, so I don't know what's common nowadays.