this post was submitted on 06 Aug 2023
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Isn't this a strange article title? The whole point of it is to show T cells don't actually get "burned out" at all. And imo it's not like the real reason is uninteresting.
Why dress the article in the exact thing it's refuting?
I mean it read to me like they were saying that cytotoxic T cells became permanently dysfunctional (the term “exhausted” is used in the paper this news article is about) when encountering cancer cells. I’m not sure I see why the title is incorrect.
IMO the title is incorrect because the common interpretation of getting "burned out" is that of the same individuals of a population losing effectiveness after working hard. The article even likens the term "exhausted" the same interpretation of the phrase:
This same quote describes the truth of the phenomenon where it's not individuals getting "exhausted", but cellular signalling permanently altering the expression of T cells to make them less and less effective.
A more correct title would be something like:
Ahh, That makes sense.